NFL Picks Against the Spread for Week 12

• I went 7-6 in my NFL ATS picks for Week 11
• For my NFL Week 12 best bets, I am targeting two favorites and one short underdog
• See below for SBD’s Week 12 expert NFL picks against the spread

Six teams are on the bye in Week 12, so Sunday and Monday will feature twelve games in total. Double-digit spreads have been few and far between this season, but there are two this weekend. Favorites of ten points or higher are 5-0 against the spread this year, so the Commanders (-10.5) and Chiefs (-10.5) could be worth a look this week.

Keep reading for my NFL Week 12 picks against the spread for every game, plus my best bets for Sunday.

NFL Week 12 Picks Against the Spread

Odds as of Friday, November 22 at ESPN BET. Be sure to claim the best ESPN BET promo code before placing your NFL Week 12 bets.

Week 12 ATS Pick #1: Packers -3 vs 49ers

This 49ers team is spiraling. It may have just been one loss, but it was gut-wrenching to watch Geno Smith run for a touchdown late in the fourth quarter to upset San Francisco last week. Once one of the Super Bowl favorites, San Francisco is not even in the NFL playoff bracket heading into Week 12. At 5-5, they are fourth in the NFC West standings, and the NFL odds have the 49ers listed as 3-point underdogs to the Packers on Sunday.

The 49ers vs Packers matchup under Kyle Shanahan is mixed. While Shanahan is 3-0 straight up against Green Bay in the playoffs, he is just 1-3 against them in the regular season.

San Francisco heads into this game banged up. Purdy is dealing with shoulder soreness, and Nick Bosa is questionable to play. Even if they both play, they will not be 100% which does not bode well for them going against Green Bay. The Packers are fourth in the league in takeaways, and Jordan Love has the offense moving, even if they did get a little lucky last week vs the Bears.

The temperature is supposed to be cold in Green Bay, so I do not expect the 49ers’ 1-3 road ATS record to improve this weekend. I’ll take the Packers to win and cover the spread.

• Pick: Packers -3 (-115)

Week 12 ATS Pick #2: Cardinals +1 vs Seahawks

On the other side of that 49ers vs Seahawks matchup last week, Seattle got a huge win. It was a hard-fought, emotional battle that was won late in the game, which can be draining for a team. The Cardinals are coming off a bye, so they have had extra time to rest and prepare for this game.

Despite the game being in Seattle, Geno Smith is just 1-5 against the spread at home this season. The Cardinals have been a surprise team. They are the current favorites to win the division, and Kyler Murray has played extremely well and has been efficient. James Conner has also been tough to bring down, so the offense is humming heading into this game.

Kyler Murray has his 2nd rushing TD 🔥

📺: #NYJvsAZ on CBS/Paramount+
📱: https://t.co/waVpO909ge pic.twitter.com/p3zE6OhoJ2

— NFL (@NFL) November 10, 2024

Seattle’s rushing defense is 27th in the league, so that bodes well for the Cardinals, who have the fifth-best rushing attack in the NFL. The Cardinals have won four in a row, and even though their last two games were against the Bears and Jets, the defense only allowed 15 points combined in those games. I like Arizona off a bye to go into Seattle and win the game.

• Pick: Cardinals +1 (-115)

Week 12 ATS Pick #3: Eagles -3 vs Rams

The Eagles and Rams play on Sunday Night Football in Week 12. Philadelphia has won their last three games against the Rams and are 4-1 against the spread on the road this season. We already know that there will be a lot of Eagles fans present at SoFi Stadium, so I feel good laying the points with a road favorite in this one.

Philadelphia has won six games in a row, and their rushing attack has been incredible behind Saquon Barkley and Jalen Hurts. The Rams are middle-of-the-pack when it comes to rushing defense and will have to sell out to stop the run. This will allow the Eagles to take advantage of LA’s vulnerable passing defense. When AJ Brown plays, Philadelphia’s offense is much better, and he should be in store for a big game on Sunday night.

Even though the Rams are getting healthier and have won four of their last five games, Philadelphia’s defense presents a major threat. They allow the least passing yards per attempt in the NFL this season and have a strong front seven. With the Rams offensive line having some injuries, the Eagles should feast on defense. I expect the Eagles to control this game and win on the road.

• Pick: Eagles -3 (-105)